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Economic synthesis of mono- and oligosaccharides represents a pressing, formidable and essentially unresolved challenge of strategic importance against the background of the emerging field of glycomics and the increasing importance of (oligo)saccharide structures in modern therapeutics. Enzyme-based methods are considered particularly promising here because of their unmatched selectivity. However, designing a scheme from monosaccharide to oligosaccharide synthesis will require an enzymatic reaction network of sub-cellular proportion that mimics cell metabolism's complexity, dynamic behaviour and energy requirements.  More...
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